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KMID : 0858520150190040218
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Journal of the Korean Society of Magnetic Resonance in Medicine
2015 Volume.19 No. 4 p.218 ~ p.223
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Application of Volumetric Analysis to Glioblastomas: a Correlation Study on the Status of the Isocitrate Dehydrogenase Mutation
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Bae Seon-Yong
Park Chul-Kee
Kim Tae-MIn
Park Sung-Hye
Kim Il-Han
Choi Seung-Hong
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Abstract
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Purpose: To investigate whether volumetric analysis based on T2WI and contrast-enhanced (CE) T1WI can distinguish between isocitrate dehydrogenase-1 mutation-positive (IDH1P) and -negative (IDH1N) glioblastomas (GBMs).
Materials and Methods: We retrospectively enrolled 109 patients with histopathologically proven GBMs after surgery or stereotactic biopsy and preoperative MR imaging. We measured the whole-tumor volume in each patient using a semiautomatic segmentation method based on both T2WI and CE T1WI. We compared the tumor volumes between IDH1P (n = 12) and IDH1N (n = 97) GBMs using an unpaired t-test. In addition, we performed receiver operating characteristic (ROC) analysis for the differentiation of IDH1P and IDH1N GBMs using the tumor volumes based on T2WI and CE T1WI.
Results: The mean tumor volume based on T2WI was larger for IDH1P GBMs than IDH1N GBMs (108.8 ± 68.1 and 59.3 ± 37.3 mm3, respectively, P = 0.0002). In addition, IDH1P GBMs had a larger tumor volume on CE T1WI than did IDH1N tumors (49.00 ± 40.14 and 22.53 ± 17.51 mm3, respectively, P < 0.0001). ROC analysis revealed that the tumor volume based on T2WI could distinguish IDH1P from IDH1N with a cutoff value of 90.25 (P < 0.05): 7 of 12 IDH1P (58.3%) and 79 of 97 IDH1N (81.4%).
Conclusion: Volumetric analysis of T2WI and CE T1WI could enable IDH1P GBMs to be distinguished from IDH1N GBMs. We assumed that secondary GBMs with IDH1P underwent stepwise progression and were more infiltrative than those with IDH1N, which might have resulted in the differences in tumor volume.
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KEYWORD
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Glioblastoma, Isocitrate dehydrogenase (IDH), Magnetic resonance imaging (MRI)
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